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  • Title: Langerhans cell histiocytosis of the maxillae in a child treated only with chemotherapy: a case report.
    Author: Cazzolla AP, Troiano G, Zhurakivska K, Maiorano E, Favia G, Lacaita MG, Marzo G, Dicuonzo F, Andresciani S, Muzio LL.
    Journal: J Med Case Rep; 2017 May 09; 11(1):130. PubMed ID: 28482919.
    Abstract:
    BACKGROUND: Langerhans cell histiocytosis is a sporadic disease caused by an uncontrolled pathogenic clonal proliferation of dendritic cells that have Langerhans cell characteristics. New treatment protocols provided by the HISTSOC-LCH-III (NCT00276757) trial show an improvement in the survival of children with langerhans cell histiocytosis. CASE PRESENTATION: We report a case of Langerhans cell histiocytosis, which presented as an osteolytic lesion of the left pre-maxillae enclosing the deciduous incisor and canine in a 7-month-old white Italian boy. He was treated with chemotherapy. He achieved complete remission after 7 months and after 24 months no signs of recurrence were observed. CONCLUSIONS: As a result of this treatment, anesthetic sequelae and loss of teeth were avoided; in addition, we prevented a loss of the vertical dimension of occlusion.
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