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  • Title: [Effect of thrombomodulin on specific thrombin functions: fibrinogen coagulation and thrombocyte aggregation].
    Author: Luk'ianenko EF, Kireeva EG, Strukova SM.
    Journal: Biull Eksp Biol Med; 1988 Nov; 106(11):517-9. PubMed ID: 2848597.
    Abstract:
    The effect of thrombomodulin (TM), prepared from rabbit lungs, on fibrinogen clotting and platelets aggregation by alpha-thrombin has been investigated. It has been established that TM caused a dose-dependent decrease in fibrinogen-clotting activity of thrombin (Ki = 14.7 +/- 1.24 nM). TM was shown to reduce thrombin-induced platelet aggregation but not to alter ADP-induced one. It was found that the kinetic parameters for hydrolysis of synthetic substrates by alpha-thrombin were not altered by TM.
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