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  • Title: Synthesis of deuterium-enriched and fluorine-substituted plinabulin derivatives and evaluation of their antitumor activities.
    Author: Ding Z, Hou Y, Wang S, Sun T, Ma M, Guan H, Li W.
    Journal: Mol Divers; 2017 Aug; 21(3):577-583. PubMed ID: 28488201.
    Abstract:
    Deuterium-enriched and fluorine-substituted compounds have been widely applied in drug discovery due to their advantages in the studies of clinical pharmacokinetics and metabolic profiles. Herein we synthesized a library of deuterated and fluorine-substituted plinabulin derivatives, and all 15 D- or F-compounds were characterized by MS, [Formula: see text] NMR and [Formula: see text]. Their antitumor activities were evaluated against human Jurkat T lymphocyte cells.
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