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  • Title: Molecular Regulation of Exercise-Induced Muscle Fiber Hypertrophy.
    Author: Bamman MM, Roberts BM, Adams GR.
    Journal: Cold Spring Harb Perspect Med; 2018 Jun 01; 8(6):. PubMed ID: 28490543.
    Abstract:
    Skeletal muscle hypertrophy is a widely sought exercise adaptation to counteract the muscle atrophy of aging and disease, or to improve athletic performance. While this desired muscle enlargement is a well-known adaptation to resistance exercise training (RT), the mechanistic underpinnings are not fully understood. The purpose of this review is thus to provide the reader with a summary of recent advances in molecular mechanisms-based on the most current literature-that are thought to promote RT-induced muscle hypertrophy. We have therefore focused this discussion on the following areas of fertile investigation: ribosomal function and biogenesis, muscle stem (satellite) cell activity, transcriptional regulation, mechanotransduction, and myokine signaling.
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