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  • Title: Increased placental sFlt-1 but unchanged PlGF expression in late-onset preeclampsia.
    Author: Ehrlich L, Hoeller A, Golic M, Herse F, Perschel FH, Henrich W, Dechend R, Huppertz B, Verlohren S.
    Journal: Hypertens Pregnancy; 2017 May; 36(2):175-185. PubMed ID: 28494189.
    Abstract:
    OBJECTIVE: To investigate whether differences between late-onset preeclampsia (PE) and intrauterine growth restriction (IUGR) can be explained by differential placental expression patters of sFlt-1, Flt-1, and placental growth factor (PlGF). METHODS: Placental tissues and maternal blood samples from seven patients with PE, five IUGR, and seven age-matched controls were studied for mRNA and protein levels as well as protein localization and expression intensity. RESULTS: Placental PlGF mRNA and protein expression were not altered by placental dysfunction while placental villous trophoblast expression intensity of PlGF was increased. CONCLUSION: High sFlt-1 concentrations may account for diminished maternal serum PlGF levels.
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