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  • Title: Quantitative Comparison of Swept-Source and Spectral-Domain OCT Angiography in Healthy Eyes.
    Author: Al-Sheikh M, Falavarjani KG, Tepelus TC, Sadda SR.
    Journal: Ophthalmic Surg Lasers Imaging Retina; 2017 May 01; 48(5):385-391. PubMed ID: 28499049.
    Abstract:
    BACKGROUND AND OBJECTIVE: To compare macular vessel density (VD) and foveal avascular zone (FAZ) area in healthy individuals using two different optical coherence tomography angiography (OCTA) devices. PATIENTS AND METHODS: In this prospective, comparative study, 25 eyes of 14 healthy subjects underwent fovea-centered 3 mm × 3 mm OCTA-imaging using the Triton (Topcon, Tokyo, Japan) and RS-3000 (Nidek, Gamagori, Japan) OCTA devices. Superficial and deep retinal layers (SRL/DRL) and FAZ were manually graded after threshold standardization to determine macular VD and area of the FAZ. RESULTS: The mean difference in the VD between the two devices was 0.105 and 0.096, and the coefficient of variation (CV) was 19.59% and 16.90% for the SRL and DRL, respectively. After skeletonization of vessels to remove variation related to vessel width, the mean difference was 0.174 mm-1 and 0.516 mm-1, and the CV was 3.49% and 1.07% for SRL and DRL, respectively. The mean difference of FAZ area was 0.001 mm2 and 0.010 mm2 in the SRL and DRL, respectively, and the CV was 2.17% and 5.74% for the SRL and DRL, respectively. CONCLUSION: Macular VD using skeletonized mapping and FAZ area in SRL and DRL were statistically similar between the two devices, demonstrating a possible comparison of quantitative values between different OCTA devices. [Ophthalmic Surg Lasers Imaging Retina. 2017;48:385-391.].
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