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  • Title: Stimulation of the pituitary adrenocortical system in man by cerulein, a cholecystokinin-8-like peptide.
    Author: Späth-Schwalbe E, Piroth L, Pietrowsky R, Born J, Fehm HL.
    Journal: Clin Physiol Biochem; 1988; 6(6):316-20. PubMed ID: 2850129.
    Abstract:
    The responses of plasma adrenocorticotropin hormone (ACTH) and cortisol to intravenous injection of cerulein (ceruletide), a decapeptide closely related to cholecystokinin octapeptide, were investigated in healthy men. In response to 16 ng/kg cerulein, plasma ACTH rose from a preinjection level of 42 +/- 11 pg/ml (mean +/- SEM) to a peak level of 81 +/- 16 pg/ml after 15 min. This ACTH increase was followed by a rise in plasma cortisol from a preinjection value of 10.3 +/- 0.9 microgram/dl to a peak value of 17.7 +/- 1.7 microgram/dl after 30 min. This is the first report of the potent stimulating effect of a cholecystokinin-8-related peptide on the pituitary-adrenal system in man.
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