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  • Title: Humoral immune responses of experimentally Eimeria ninakholyakimovae-infected goat kids.
    Author: Matos L, Muñoz MDC, Molina JM, Ferrer O, Rodríguez F, Pérez D, López AM, Martín S, Hermosilla C, Taubert A, Ruiz A.
    Journal: Comp Immunol Microbiol Infect Dis; 2017 Apr; 51():60-65. PubMed ID: 28504097.
    Abstract:
    Although cellular immune reactions seem to be crucial for protective immune responses in Eimeria spp. infections, there are also evidences on an active involvement of the humoral counterpart. In the present study, we have analyzed the humoral response of goat kids subjected to primary and challenge infections with Eimeria ninakholyakimovae. Specific levels of IgG and IgM in serum samples and IgA in the ileal mucus were estimated. In infected kids, significantly increased levels of IgG were observed from 3 weeks post infection onwards in addition to an enhancement of specific IgM and secretory IgA levels. A wide range of peptides of sporulated oocyst antigen (SOA) was recognized by specific IgG as determined by immunoblotting. However, no correlations were found between immunoglobulin levels and OPG counts after challenge infection. Overall, these data indicate a significant specific humoral response of E. ninakohlyakimovae-infected goat kids that does not seem to convey immunoprotection. Further studies should be addressed to clarify if the lack of correlation might be associated to the type of antigen used for the immunoenzimatic assays, the age of the animals or other factors.
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