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Pubmed for Handhelds

PUBMED FOR HANDHELDS

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  • Title: Controlled Release of Plectasin NZ2114 from a Hybrid Silicone-Hydrogel Material for Inhibition of Staphylococcus aureus Biofilm.
    Author: Klein K, Grønnemose RB, Alm M, Brinch KS, Kolmos HJ, Andersen TE.
    Journal: Antimicrob Agents Chemother; 2017 Jul; 61(7):. PubMed ID: 28507110.
    Abstract:
    Staphylococcus aureus is a major human pathogen in catheter-related infections. Modifying catheter material with interpenetrating polymer networks is a novel material technology that allows for impregnation with drugs and subsequent controlled release. Here, we evaluated the potential for combining this system with plectasin derivate NZ2114 in an attempt to design an S. aureus biofilm-resistant catheter. The material demonstrated promising antibiofilm properties, including properties against methicillin-resistant S. aureus, thus suggesting a novel application of this antimicrobial peptide.
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