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  • Title: Differences in the mechanism of induction of interferon-alpha by herpes simplex virus and herpes simplex virus-infected cells.
    Author: Capobianchi MR, Malavasi F, Di Marco P, Dianzani F.
    Journal: Arch Virol; 1988; 103(3-4):219-29. PubMed ID: 2850784.
    Abstract:
    The cellular source of IFN alpha after induction with Herpes simplex virus type-1 (HSV) and HSV-infected fibroblasts was investigated by using human peripheral blood mononuclear cell (PBMC) populations, purified according to conventional procedures, and which included T- and B-lymphocytes as well as monocytes. It appears that the cells responding to HSV virions are monocytes, whereas the PBMC population induced by HSV-infected cells is represented by B-lymphocytes. Furthermore, by using monoclonal antibody (MoAb) to HLA class I and class II products, it appears that different membrane structures are involved in the induction of IFN by HSV virions, as opposed to HSV-infected cells. In fact, most anti-HLA class II MoAbs inhibit IFN induction by HSV-infected cells, and not IFN induction by HSV virions.
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