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  • Title: [Quantitative patterns of tubocurarine action on the synaptic potentials of frog muscle].
    Author: Grigor'ev VM, Danilov AF, Skliarov AI.
    Journal: Fiziol Zh SSSR Im I M Sechenova; 1988 Sep; 74(9):1228-34. PubMed ID: 2850942.
    Abstract:
    The dependence of amplitude of synaptic potentials (EPP and mEPP) upon the d-tubocurarine concentration was studied in the frog cutaneous pectoral muscle. In the presence of d-tubocurarine up to 5 x 10(-7) M, the amplitude of EPP and mEPP decreased to the extent which strictly followed competitive action of d-tubocurarine. At a higher concentration, the inhibition of synaptic potentials was stronger than would be expected assuming that d-tubocurarine can only act as a competitive antagonist.
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