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  • Title: Viral and cellular deoxyribonucleases are associated with herpes simplex virus replicative intermediates.
    Author: Turco A, Pignatti PF.
    Journal: Microbiologica; 1988 Oct; 11(4):321-8. PubMed ID: 2851087.
    Abstract:
    The presence of viral and cellular deoxyribonucleases was investigated in partially purified HSV replicative intermediates (nucleoprotein complexes) and nucelocapsids prepared from BHK-21 cell cultures infected with herpes simplex virus type 1. The 85kd virus-coded alkaline nuclease was detected by Western blotting experiments in infected cell extracts 7 h after infection, and was identified in viral DNA containing nucleoprotein complexes at 18 h after infection. With activity gel experiments, three cellular deoxyribonucleases were detected in mock-infected cells. Two of them were present in infected cell extracts, and one of them (50kd) was detected in nucleocapsids at 9 h P.I., and in nucleoprotein complexes at 18 h P.I. These data indicate a possible role of viral nuclease in the biosynthesis of late replicative intermediates, and suggest an active involvement of the nuclear matrix in viral replication.
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