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  • Title: Hypoxia-based strategies for regenerative dentistry-Views from the different dental fields.
    Author: Müller AS, Janjić K, Lilaj B, Edelmayer M, Agis H.
    Journal: Arch Oral Biol; 2017 Sep; 81():121-130. PubMed ID: 28511093.
    Abstract:
    The understanding of the cell biological processes underlying development and regeneration of oral tissues leads to novel regenerative approaches. Over the past years, knowledge on key roles of the hypoxia-based response has become more profound. Based on these findings, novel regenerative approaches for dentistry are emerging, which target cellular oxygen sensors. These approaches include hypoxia pre-conditioning and pharmacologically simulated hypoxia. The increase in studies on hypoxia and hypoxia-based strategies in regenerative dentistry highlights the growing attention to hypoxia's role in regeneration and its underlying biology, as well as its application in a therapeutic setting. In this narrative review, we present the current knowledge on the role of hypoxia in oral tissues and review the proposed hypoxia-based approaches in different fields of dentistry, including endodontics, orthodontics, periodontics, and oral surgery.
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