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  • Title: Tumour necrosis factors modulate the affinity state of the leukotriene B4 receptor on human neutrophils.
    Author: Brom J, Knöller J, Köller M, König W.
    Journal: Immunology; 1988 Dec; 65(4):647-9. PubMed ID: 2851543.
    Abstract:
    Pre-incubation of human polymorphonuclear granulocytes with recombinant human tumour necrosis factors (TNF) revealed a time- and dose-dependent reduction of the expression of leukotriene B4-receptor sites. Analysis of the binding data by Scatchard plots showed a shift from a heterologous receptor population (indicating high- and low-affinity subsets) to a homologous population. From the results it is considered that TNF can influence host defence through the modulation of leukotriene B4 receptor affinity.
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