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  • Title: Au-Cu core-shell nanocube-catalyzed click reactions for efficient synthesis of diverse triazoles.
    Author: Madasu M, Hsia CF, Huang MH.
    Journal: Nanoscale; 2017 Jun 01; 9(21):6970-6974. PubMed ID: 28517020.
    Abstract:
    Au-Cu core-shell nanocubes and octahedra synthesized in aqueous solution were employed to catalyze a 1,3-dipolar cycloaddition reaction between phenylacetylene and benzyl azide in water at 50 °C for 3 h. Interestingly, the nanocubes were far more efficient in catalyzing this reaction, giving 91% yield of a regioselective 1,4-triazole product, while octahedra only recorded 46% yield. The Au-Cu nanocubes were subsequently employed to catalyze the click reaction between benzyl azide and a broad range of aromatic and aliphatic alkynes. The product yields ranged from 78 to 99%. Clearly the Au-Cu cubes exposing {100} surfaces are an excellent and green catalyst for click reactions.
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