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  • Title: [Compensation for behavioral disorders caused by 6-hydroxydopamine administration via the transplantation of embryonic tissue from the locus coeruleus in rats].
    Author: Semenova TP, Bragin AG, Grishchenko NI, Nesterova IV, Vinogradova OS.
    Journal: Zh Vyssh Nerv Deiat Im I P Pavlova; 1988; 38(5):872-80. PubMed ID: 2851897.
    Abstract:
    Neonatal injection of 6-OHDA produces defects of sensory attention and emotional reactions in the rats. Possibility of compensation of these behavioural defects by the grafts of embryonal locus coeruleus (LC) tissue into the neocortex was investigated in male rats of the Wistar strain. Histological analysis revealed spindle-shaped and oval cells typical of LC in the neocortex of all animals with LC grafts. Characteristic green fluorescence of these noradrenergic cells was demonstrated by Falck's method. Normalization of the orienting reaction to sensory (tactile and visual) stimuli, as well as of frustration effects was observed in the animals with LC grafts, but not in the control groups with saline injections or hippocampal grafts. The data show the possibility of stable compensation of the behavioural defects resulting from neonatal injection of 6-OHDA by the grafts of embryonal tissue containing noradrenergic neurones.
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