These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Receptor autoradiographic evidence of specific brain natriuretic peptide binding sites in the porcine subfornical organ.
    Author: Niwa M, Shigematsu K, Kurihara M, Kataoka Y, Maeda T, Nakao K, Imura H, Matsuo H, Tsuchiyama H, Ozaki M.
    Journal: Neurosci Lett; 1988 Dec 19; 95(1-3):113-8. PubMed ID: 2852316.
    Abstract:
    Specific binding sites of brain natriuretic peptide (BNP), a newly discovered peptide in the subfornical organ (SFO) of porcine brain were investigated, following incubation of related tissue sections with 125I-BNP, then using autoradiography and an image analysis coupled with computer-assisted microdensitometry. Specific 125I-BNP binding sites were found to be localized in the SFO, an area densely labeled by 125I-alpha-rat atrial natriuretic peptide and 125I-(Sar1,Ile8)-angiotensin II. Specific 125I-BNP binding to the SFO was displaced by unlabeled BNP, with a high affinity, and was calculated to be Ka = 0.385 x 10(-9) M and Bmax = 40.1 fmol/mg using a LIGAND computer program. Acquisition of these present findings enhances our knowledge of the physiology of BNP, atrial natriuretic peptides and angiotensin II system in the SFO.
    [Abstract] [Full Text] [Related] [New Search]