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  • Title: Electrogenic Na+/HCO3- cotransport in neuroglia.
    Author: Astion ML, Orkand RK.
    Journal: Glia; 1988; 1(5):355-7. PubMed ID: 2852638.
    Abstract:
    Membrane potential recording from glial cells in Necturus optic nerve in the presence of 2 mM Ba++, which was added to block the K+ conductance, gave the following results. 1) In HCO3- -free, low-Na+ solutions (11% of control; Na+ replaced with N-methyl-D-glucamine), the hyperpolarizing effect of adding 10 mM HCO3- was reduced by approximately 80%. 2) 4-acetamido-4'-isothiocyanato-stilbene-2,2'-disulfonic acid (SITS, 0.1 or 1 mM) reduced the effect of HCO3- by at least 50%. 3) In the presence of HCO3-, reduction of Na+ caused a depolarization which was much larger than that observed in nominally HCO3- -free solutions. These observations indicate the presence in the glial membrane of an electrogenic Na+/HCO3- cotransporter in which the stoichiometry of HCO3- to Na+ is greater than 1.
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