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  • Title: Megastigmane glucosides isolated from Dichrocephala benthamii.
    Author: Song B, Si JG, Yu M, Tian XH, Ding G, Zou ZM.
    Journal: Chin J Nat Med; 2017 Apr; 15(4):288-291. PubMed ID: 28527514.
    Abstract:
    The present study was designed to investigate the chemical constituents of the whole herb of Dichrocephala benthamii. A new megastigmane glucoside (compound 1), together with its four known analogues (compounds 2-5), was obtained. Their structures were elucidated on the basis of spectroscopic analyses (UV, IR, MS, and 1D and 2D NMR). The absolute configuration of compound 1 was assigned on the basis of CD method and chemical evidence. In addition, their cytotoxicity against human hepatoma cells (HepG-2) was evaluated by the MTT method. Compound 5 showed weak activity against HepG-2, while the other compounds did not show remarkable inhibitory effects.
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