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  • Title: [The density of lymphocyte beta 2-adrenoreceptors and blood plasma catecholamines in patients with dilated cardiomyopathy].
    Author: Gabrusenko SA, Naumov VG, Krasnikova TL, Korichneva IL, Masenko VP.
    Journal: Biull Vsesoiuznogo Kardiol Nauchn Tsentra AMN SSSR; 1988; 11(2):6-9. PubMed ID: 2852942.
    Abstract:
    27 patients with dilated cardiomyopathy (DCM) complicated by heart failure (HF) of stages I-IIB were studied. The density of lymphocyte beta 2-adrenoceptors decreased significantly as HF progressed. The level of circulating catecholamines (epinephrine, norepinephrine) was significantly higher in patients were severe HF, which probably caused more evident decrease in lymphocyte beta 2-adrenoceptors density in these patients. This point of view was confirmed by the data of correlation-regression analysis between the general beta 2-adrenoceptors density and hemodynamics data. The identified changes in the number of adrenoceptors reflect the process of cellular receptors desensitization. They should be considered as a possible mechanism of HF development on a molecular level that cause development of refractoriness to routine therapy.
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