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  • Title: Lanthanide-based peptide biosensor to monitor CDK4/cyclin D kinase activity.
    Author: González-Vera JA, Bouzada D, Bouclier C, Eugenio Vázquez M, Morris MC.
    Journal: Chem Commun (Camb); 2017 Jun 01; 53(45):6109-6112. PubMed ID: 28530267.
    Abstract:
    We describe a lanthanide biosensor that responds to CDK4 kinase activity in melanoma cell extracts through a significant and dose dependent increase in luminescence, thanks to sensitization of a DOTA[Tb3+] complex incorporated into a CDK4 substrate peptide by a unique tryptophan residue in an adjacent phosphoaminoacid binding moiety.
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