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  • Title: [The effect of naloxone on basal and maximum gastric secretion in patients with chronic duodenal ulcer].
    Author: Markiewicz K, Lukin M.
    Journal: Dtsch Z Verdau Stoffwechselkr; 1988; 48(3-4):138-44. PubMed ID: 2853044.
    Abstract:
    In 22 men with chronic duodenal ulcer and 15 healthy men effect of a single intravenous injection of 2 mg of naloxone on basis and pentagastrin-stimulated acid output was determined. Naloxone was found to induce a significant decrease in BAO in chronic duodenal ulcer patients; a decrease in BAO in healthy men was insignificant. MAO was not affected by naloxone in both groups. Gastric secretions of potassium, sodium, chloride and mucoprotein were proportional to changes in the volume of the gastric juice. It seems that opioid agonists may play some role in the pathogenesis of duodenal ulcers.
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