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  • Title: Neuron-specific enolase in the diagnosis of small-cell lung cancer with pleural effusion: a negative report.
    Author: Pettersson T, Klockars M, Fröseth B.
    Journal: Eur Respir J; 1988 Aug; 1(8):698-700. PubMed ID: 2853080.
    Abstract:
    We measured the concentration of neuron-specific enolase (NSE) and carcinoembryonic antigen (CEA) in the serum and pleural fluid of 53 patients with pleural effusions, including seven patients with small-cell lung cancer (SCLC). High levels (above 12.5 micrograms.l-1) of NSE in pleural fluid were observed in five patients with SCLC (sensitivity 71%). However, pleural fluid NSE levels were also increased in five patients with other types of cancer and in four patients with non-malignant inflammatory diseases (specificity 80%). We conclude that although SCLC with pleural effusion can be associated with elevated pleural fluid NSE activity, this increase in enzyme levels is not specific for malignancy.
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