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  • Title: Association of CXCR4, CCR7, VEGF-C and VEGF-D expression with lymph node metastasis in patients with cervical cancer.
    Author: Dai Y, Tong R, Guo H, Yu T, Wang C.
    Journal: Eur J Obstet Gynecol Reprod Biol; 2017 Jul; 214():178-183. PubMed ID: 28535405.
    Abstract:
    OBJECTIVE: We attempted to investigate the expression of CXCR4, CCR7, VEGF-C and VEGF-D in cervical cancer specimens, and the association between CXCR4, CCR7, VEGF-C and VEGF-D expression with the clinicopathological parameters of patients with cervical cancer. STUDY DESIGN: 57 tissue microarrays including 9 normal cervical tissues and 48 cervical cancer tissues were purchased from Biomax. The association between CXCR4, CCR7, VEGF-C and VEGF-D expression with the clinicopathological parameters were evaluated. Then immunohistochemistry was used to assess the expression of CXCR4, CCR7, VEGF-C and VEGF-D in cervical cancer specimens. Finally, Spearman correlations were used for the correlation analyses between CXCR4, CCR7, VEGF-C and VEGF-D. RESULTS: We revealed that CXCR4 expression was significantly higher in patients with squamous cell carcinomas (P=0.002) and lymph node metastasis (P=0.038), while CCR7 expression was significantly elevated in patients with lymph node metastasis (P=0.037). VEGF-C expression was markedly up-regulated in patients exhibiting FIGO stage II-III tumors (P=0.015) and lymph node metastasis (P=0.038), while VEGF-D expression was obviously increased in patients displaying FIGO stage II-III tumors (P=0.025), squamous carcinomas (P=0.017) and lymph node metastasis (P=0.037). The correlation analysis indicated that CXCR4, CCR7, VEGF-C and VEGF-D expression have a significant correlation to each other. CONCLUSION: These results suggested that CXCR4, CCR7, VEGF-C and VEGF-D expression might have synergistic effects on the lymph node metastasis in patients with cervical cancer.
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