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  • Title: Interaction of different nucleotides with Ca-release channels from heavy sarcoplasmic reticulum.
    Author: Rubtsov AM, Smirnova MB, Boldyrev AA.
    Journal: Biochem Int; 1988 Oct; 17(4):629-36. PubMed ID: 2853630.
    Abstract:
    Calcium accumulation and release from the heavy fraction of sarcoplasmic reticulum vesicles have been studied in the presence of different nucleotides with the use of the Ca-sensitive dye antipyrylazo III for monitoring of the free Ca2+ concentration. The calcium- and caffeine-induced Ca2+ release is observed only with ATP but not with any of nonadenine nucleotides used as substrates for the Ca-pump. Adenine nucleotides provide for a rapid ruthenium red sensitive Ca2+ release from the vesicles, when nonadenine nucleotides are used as energy sources for Ca2+ uptake. A comparison of the nucleotides interaction with Ca-channels and Ca-ATPase supports the hypothesis that Ca-ATPase is involved in the operation of Ca-channels.
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