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  • Title: The effects of amphetamine on neuromuscular transmission in the lobster.
    Author: Turkanis SA, Partlow LM, Karler R.
    Journal: Neuropharmacology; 1988 Dec; 27(12):1221-5. PubMed ID: 2854225.
    Abstract:
    In vitro electrophysiological techniques were used on an excitatory neuromuscular junction of a walking-limb stretcher muscle of the lobster in order to define the pharmacology of amphetamine on a glutamatergic synapse. A single electrical stimulus in the presence of the drug produced a train of action potentials in the axon innervating the neuromuscular junction, resulting in a staircase-like enhancement of the evoked excitatory junction potential; both effects were antagonized by relatively small doses of haloperidol. In contrast, amphetamine reduced the amplitude of the spontaneous miniature junctional potential, suggesting a postsynaptic site of action; this depressant response to the drug was not antagonized by haloperidol. The data demonstrate that amphetamine concomitantly produces both excitation and depression at a single synapse.
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