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  • Title: [Effect of dihydropyridines on cation transport across the skeletal muscle membrane in the frog].
    Author: Shvinka NE, Caffier G, Vinogradova TA, Velena AKh, Bisenieks EA.
    Journal: Tsitologiia; 1988 Oct; 30(10):1254-60. PubMed ID: 2854317.
    Abstract:
    2,6-Dimethyl-3,5-dimethoxycarbonyl-4-(o-difluromethoxyphenyl)- 1,4-dihydropyridine (ryodipine) blocks Ca-channels in phasic muscle fibres from ileofibularis and semitendinosus muscle of Rana esculenta. Ryodipine and some other newly synthesized dihydropyridines (10(-7)-10(-4) M) exerted a slight, if any, effect on the steady-state of potassium chord conductance in isotonic K+-sulfate solution. The effluxes of potassium and rubidium from the sartorius muscle of Rana temporaria also remained unchanged after addition of 2 x 10(-4) M ryodipine. Thus, the nonspecific dihydropyridine effect on ion transport seems to be poorly expressed.
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