These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


PUBMED FOR HANDHELDS

Search MEDLINE/PubMed


  • Title: [Comparative analysis of the antiamnesic action of a blockade of the benzodiazepine-GABA-ionophore complex and of an activation of the dopaminergic system in the brain of mice].
    Author: Dubrovina NI, Il'iuchënok RIu.
    Journal: Zh Vyssh Nerv Deiat Im I P Pavlova; 1988; 38(6):1054-9. PubMed ID: 2854342.
    Abstract:
    In experiments on mice by the method of conditioned reaction of passive avoidance and amnesia elicited by the animal delay in the dangerous compartment immediately after electrocutaneous stimulation, antiamnestic effect is demonstrated of pharmacological influences, changing the activity of benzodiazepine-GABA-ionophore complex and dopaminergic system. Comparative analysis of the efficiency of neuropharmacological substances of different actions on synaptic apparatus of the studied transmitter systems in amnesia reduction showed that the greatest effect of improving the reproduction of the conditioned habit was that of the bupropion, the highly specific blockator of dopamine reverse absorption. The obtained results testify that amnesia development is based on activation of the inhibitory GABAergic brain processes and disturbance of dopaminergic system functioning.
    [Abstract] [Full Text] [Related] [New Search]