These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Effect of K+ channel blockers on anti-immunoglobulin-induced murine B cell proliferation.
    Author: Gollapudi SV, Vayuvegula BS, Thadepalli H, Gupta S.
    Journal: J Clin Lab Immunol; 1988 Nov; 27(3):121-5. PubMed ID: 2854569.
    Abstract:
    Ion channels play an important role in the transmission of signals across cell membrane in a variety of cell types. Recent studies indicate that normal murine splenic B lymphocytes express voltage gated K+ channels. In the present study, we examined the influence of K+ channel blockers 4 aminopyridine (4 AP) and tetraethyl ammonium, and Ca++ activated K+ channel blocker quinine on anti-immunoglobulin (anti-Ig)-induced B cell proliferation. The results show that ion channel blockers inhibited DNA synthesis in B cells induced by anti-Ig. 4 AP also inhibited protein synthesis but had no effect on the expression of surface immunoglobulin. 4 AP exerted its maximum suppressive effects on DNA synthesis when added within the first 24 hours after the onset of culture with anti-Ig. The inhibition of DNA synthesis by 4 AP was reversible upon its removal from culture. These studies show a role of K+ channels in B cell DNA and protein synthesis.
    [Abstract] [Full Text] [Related] [New Search]