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  • Title: [The effect of spermine on transport of Ca2+ ions in brain mitochondria].
    Author: Karadzhov IuS, Kudzina LIu, Zinchenko VP.
    Journal: Biofizika; 1988; 33(6):1001-5. PubMed ID: 2854745.
    Abstract:
    The effect of spermine (50-400 microM) on the Ca-transporting system of brain mitochondria was studied. In a medium containing Mg2+ and ATP, spermine facilitates the accumulation of Ca2+ by decreasing Km of the uniporter. Spermine inhibits Na-stimulated Ca2+ efflux; this effect is dependent on the ionic strength of the medium--it is decreased when KCl concentration is increased from 20 to 120 mM. Spermine (200 microM) decreases (by 50%) the steady state concentration of Ca2+ maintained by mitochondria. The importance of spermine as a regulator of Ca2+-transport in brain mitochondria is discussed.
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