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  • Title: Elevated lactate dehydrogenase isoenzyme 1 as a tumour marker in patients with germ cell testicular tumours.
    Author: Winkle DC, Clague AE, Gardiner RA.
    Journal: Aust N Z J Surg; 1988 Sep; 58(9):737-41. PubMed ID: 2854968.
    Abstract:
    In a series of 50 patients with testicular tumours evaluated prior to orchidectomy, 12 out of 19 with pure seminoma and seven out of 31 with non-seminomatous or mixed seminomatous and non-seminomatous germ cell tumours had elevated plasma lactate dehydrogenase isoenzyme 1 concentrations. In contrast, seven of the 19 seminoma patients had elevated serum human chorionic gonadotrophin (hCG) concentrations and 25 of the 31 non-seminomatous and mixed seminomatous and non-seminomatous germ cell tumour patients had elevations of hCG and/or alpha-fetoprotein. Using these three markers, 12 out of 19 seminoma patients and 27 out of 31 non-seminomatous or mixed seminomatous and non-seminomatous tumour patients were positive for one or more of these tumour markers.
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