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  • Title: Clinical Features and Outcome of Surgical Patients with Non-B Non-C Hepatocellular Carcinoma.
    Author: Wakiyama S, Matsumoto M, Haruki K, Gocho T, Sakamoto T, Shiba H, Futagawa Y, Ishida Y, Yanaga K.
    Journal: Anticancer Res; 2017 Jun; 37(6):3207-3213. PubMed ID: 28551666.
    Abstract:
    AIM: To investigate the clinical characteristics and prognosis of surgical patients with non-B non-C hepatocellular carcinoma (NBNC-HCC) compared to those of hepatitis B virus (HBV)- and hepatitis C virus (HCV)-HCC. PATIENTS AND METHODS: Clinical data and outcomes were compared among the three groups. Prognostic factors of patients with NBNC-HCC were investigated. RESULTS: Compared to HBV-HCC, patients with NBNC-HCC had higher chance of hypertension (HTN) (p<0.01), diabetes mellitus (DM) and body mass index (BMI) >25 kg/m2 Compared to HCV-HCC, patients with NBNC-HCC had higher incidence of DM and higher BMI >25 kg/m2 (p<0.01). There were no significant differences in overall survival (OS) rate among the three groups. In patients with NBNC-HCC, albumin (Alb; p<0.05) was an independent prognostic factor of OS, while Alb and α-fetoprotein (AFP) were independent prognostic factors of disease-free survival (DFS; p<0.01 each). CONCLUSION: Surgical patients with NBNC-HCC often have concomitant DM, HTN and high BMI, for whom factors related to prognosis were Alb and AFP.
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