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  • Title: Oligodeoxynucleotides containing 2'-amino-LNA nucleotides as constrained morpholino phosphoramidate and phosphorodiamidate monomers.
    Author: Vejlegaard K, Paul S, Kosbar T, Wengel J, Caruthers MH.
    Journal: Bioorg Med Chem Lett; 2017 Jul 15; 27(14):3173-3176. PubMed ID: 28552336.
    Abstract:
    Incorporation in a 2'→5' direction of a phosphorodiamidite 2'-amino-LNA-T nucleotide as the morpholino phosphoramidate and N,N-dimethylamino phosphorodiamidate monomers into six oligonucleotides is reported. Thermal denaturation studies showed that the novel 2'-amino-LNA-based morpholino monomers exert a destabilizing effects on duplexes formed with complementary DNA and RNA.
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