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  • Title: Treatment of cytomegalovirus pneumonitis with ganciclovir in renal transplantation.
    Author: Stoffel M, Pirson Y, Squifflet JP, Lamy M, Gianello P, Alexandre GP.
    Journal: Transpl Int; 1988 Dec; 1(4):181-5. PubMed ID: 2855305.
    Abstract:
    Ganciclovir, also called DHPG, was administered intravenously to eight renal transplant recipients with life-threatening cytomegalovirus (CMV) pneumonitis. One patient died of pulmonary failure; a favorable clinical response was observed in the seven others. In one patient, CMV pneumonitis recurred but responded well to a second course of the drug. At no time was the immunosuppressive regimen completely stopped in the seven surviving patients. Six of them maintained a good renal function 1-11 months after treatment with ganciclovir. No toxic effect was detected during therapy. We conclude that ganciclovir appears to be a promising and effective treatment for CMV pneumonitis after renal transplantation.
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