These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: [Effects of converting enzyme inhibition by enalapril on renal hemodynamics in essential arterial hypertension].
    Author: Chaignon M, Moreau L.
    Journal: Presse Med; 1988 Oct 08; 17(34):1745-7. PubMed ID: 2855543.
    Abstract:
    The effects of enalapril, an angiotensin-converting enzyme inhibitor, on renal haemodynamics were studied in 10 patients with moderates essential hypertension and no renal failure. Renal blood flow and glomerular filtration were measured (by I 131-hippuran and I 125-iothalamate clearances respectively), before ("placebo period"), and after 15 days of treatment with enalapril 40 mg/day. The drug clearly had an antihypertensive effect: systolic pressure fell from 169 +/- 4 to 149 +/- 5 mmHg (P less than 0.01), and diastolic pressure from 111 +/- 3 to 94 +/- 3 mmHg (P less than 0.01). Enalapril induced marked renal vasodilatation: renal vascular resistance decreased from 0.18 +/- 0.01 to 0.14 +/- 0.01 A.U. (P less than 0.01); renal blood flow was moderately increased (from 764 +/- 43 to 829 +/- 43 ml/min/1.73 m2, P less than 0.05), while glomerular filtration rate remained unmodified (118 +/- 4 versus 120 +/- 6 ml/min/1.73 m2, NS). Under enalapril, the filtration fraction decreased from 0.29 +/- 0.01 to 0.26 +/- 0.01 (P less than 0.01). These results confirmed that enalapril produces dilatation of both the afferent and efferent arterioles - a mechanism that might lower perfusion pressure in the glomerular capillary vessels.
    [Abstract] [Full Text] [Related] [New Search]