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  • Title: Fetal response to intramuscular epinephrine for anaphylaxis during maternal penicillin desensitization for secondary syphilis.
    Author: Wu SS, Abraham T, Michaud C, Peppers B, Ward A, Buchner SE, Teba CV, Tcheurekdjian H, Hostoffer R, Jhaveri D.
    Journal: J Matern Fetal Neonatal Med; 2018 Aug; 31(16):2223-2225. PubMed ID: 28562129.
    Abstract:
    Penicillin desensitization is indicated in pregnant patients with severe allergies to penicillin with syphilis. The immediate effects of intramuscular epinephrine on the fetus during desensitization remain unreported. We describe a pregnant patient with secondary syphilis and penicillin allergy who developed anaphylaxis during penicillin desensitization. Anaphylaxis resolved after administration of intramuscular epinephrine. Throughout the procedure, continuous electronic fetal monitoring showed a stable fetus without a decrease in variability, tachycardia, decelerations, or signs of fetal distress. This case showed that intramuscular epinephrine is effective in treatment of anaphylaxis in a pregnant patient with little to no immediate effects on the fetus.
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