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  • Title: Haemodynamic effects of pindolol in essential hypertension with special reference to resistance vessels in the forearm during maximal vasodilatation.
    Author: Gretzer I, Dunér H, Lagerbäck B.
    Journal: J Hypertens Suppl; 1985 Dec; 3(3):S215-7. PubMed ID: 2856707.
    Abstract:
    Eleven patients, mean age 45 years, with previously untreated hypertension (WHO stage I) were treated over 16 months with pindolol in dosages of 5-30 mg/day. The effects on blood pressure and peripheral vascular resistance (PR) were studied before and after 2 and 16 months of treatment. Recordings were performed at rest, and after maximal vasodilatation obtained by ischaemic work to exhaustion with a hand-ergometer. Blood pressure was significantly reduced after both 2 and 16 months of treatment (P < 0.001). During treatment small reductions in heart rate were seen at rest but not after maximal vasodilatation (P < 0.02 and NS, respectively). At rest there was a great variability and no significant changes in PR. Peripheral vascular resistance after maximal vasodilatation was significantly reduced after both 2 and 16 months of treatment (P < 0.005 and P < 0.01, respectively). We conclude that long-term treatment with pindolol may give a regression of structural vascular changes.
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