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  • Title: Lymphocyte cell membrane handling of sodium and blood pressure control during salt restriction in normotensive subjects.
    Author: Jest P, Pedersen KE, Klitgaard NA, Arentoft A, Nielsen JR.
    Journal: J Hypertens Suppl; 1985 Dec; 3(3):S65-7. PubMed ID: 2856826.
    Abstract:
    Intralymphocytic sodium and potassium concentrations, 22Na efflux rate constants (EFRC) and blood pressures (BPs) were studied in nine normotensive young males without a history of essential hypertension before, during and after 5 weeks of severe sodium depletion. Diastolic and median BPs decreased significantly as estimated by both ambulatory and home readings. A slight decrease in intralymphocytic potassium content and a significant increase in sodium content was found. Measurements of 22Na-EFRC were reduced by 15% in the ouabain-sensitive component of the sodium pump, while the absolute sodium efflux stayed constant during sodium depletion. These results are evidence of a primary inhibition of the sodium pump during salt restriction in normotensives.
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