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  • Title: A cloned MCGF cDNA encodes a multilineage hematopoietic growth factor: multiple activities of interleukin 3.
    Author: Rennick DM, Lee FD, Yokota T, Arai KI, Cantor H, Nabel GJ.
    Journal: J Immunol; 1985 Feb; 134(2):910-4. PubMed ID: 2856931.
    Abstract:
    We recently isolated from a mouse T cell cDNA library a full-length clone that encodes a mast cell growth factor (1). On the basis of sequence homologies, this cloned factor must be similar if not identical to purified interleukin 3 (IL 3) (2, 3). Here, we report the first biologic characterization of the cloned gene product expressed in COS-7 monkey cells. Our results establish that a single molecular species promotes the growth and differentiation of a wide spectrum of hematopoietic cell types, including multipotential stem cells and various committed progenitor cells. The relationship of cloned IL 3 to other colony-stimulating factors is discussed.
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