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  • Title: Interaction of estramustine phosphate with microtubule-associated proteins.
    Author: Wallin M, Deinum J, Fridén B.
    Journal: FEBS Lett; 1985 Jan 07; 179(2):289-93. PubMed ID: 2857133.
    Abstract:
    We have reported [(1984) Cancer Res., in press] that estramustine phosphate inhibits microtubule assembly and disassembled preformed microtubules. We now present evidence that estramustine phosphate inhibits microtubule assembly by binding to the microtubule-associated proteins. We have found that: additional microtubule-associated proteins relieved the inhibition of assembly by estramustine phosphate; 3H-labelled estramustine phosphate bound predominantly to the microtubule-associated proteins; and the content of the microtubule-associated proteins was reduced in taxol reversed estramustine phosphate-inhibited microtubules.
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