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  • Title: Serum inhibitory factors (SIF) are of prognostic value in acute viral hepatitis.
    Author: Wiedmann KH, Brattig NW, Diao GD, Schomerus H, Dölle W, Berg PA.
    Journal: Lancet; 1985 Feb 09; 1(8424):309-12. PubMed ID: 2857365.
    Abstract:
    Serum inhibitory factors (SIF) were analysed in relation to the natural course of acute viral hepatitis in 81 patients followed over a period of 1 year. 63 patients recovered completely (group 1), and 18 had a protracted course of hepatitis (group 2) as shown by persistent transaminase activity 6 months after onset. 11 patients in group 2 still had signs of liver disease after 1 year. A gradual fall of SIF activity (in 47 patients) heralded resolving hepatitis, whereas persistence of SIF (in 8 patients) correlated with inflammatory activity and failure of hepatitis B viral antigen elimination. Absence of SIF activity was associated with either an uncomplicated or a chronic course of hepatitis in 23 and 3 patients, respectively. Repeated determination of SIF may help to predict the final outcome of hepatitis. Both excessive and failure of SIF production may result in the development of chronic liver disease.
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