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  • Title: Monoclonal antibody to enkephalins with binding characteristics similar to opiate receptor.
    Author: Deguchi T, Yokoyama E.
    Journal: Biochem Biophys Res Commun; 1985 Jan 16; 126(1):389-96. PubMed ID: 2857562.
    Abstract:
    Monoclonal antibodies to enkephalins were established by immunization of mice with met-enkephalin, leu-enkephalin or both. Twenty-three clones with a high titer were classified into 6 types according to the binding properties to enkephalins and their derivatives. Antibody LM 239 showed binding characteristics similar to opiate receptor. It has a very high affinity to enkephalins and their derivatives which have a potent opioid activity, but a low affinity to enkephalin derivatives which devoid of opioid activity. The binding of 3H-met-enkephalin to the antibody was inhibited by naloxone and morphine, although the ID50 values were considerably higher than the Ka values of the alkaloids to opiate receptor.
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