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  • Title: Vascular alpha 2-adrenoceptors can mediate nerve stimulation-evoked contractions.
    Author: Docherty JR, Hyland L.
    Journal: Clin Sci (Lond); 1985; 68 Suppl 10():117s-120s. PubMed ID: 2857605.
    Abstract:
    It is now established that alpha 2-adrenoceptors can be present on vascular smooth muscle as targets for exogenous agonists, but some controversy exists as to whether these vascular alpha 2-receptors may also be the target for neurally released noradrenaline. In human saphenous vein we have found evidence that the alpha 2-antagonist yohimbine in low concentrations (0.01 mumol/l) can significantly inhibit stimulation-evoked contractions, whereas the alpha 1-antagonist prazosin is more than ten times less potent. It is concluded that, at least in some tissues, neuro-effector transmission can be mediated by vascular alpha 2-adrenoceptors.
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