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  • Title: Acute and chronic regulation of alpha 2-adrenoceptor number and function in man.
    Author: Jones CR, Hamilton CA, Whyte KF, Elliott HL, Reid JL.
    Journal: Clin Sci (Lond); 1985; 68 Suppl 10():129s-132s. PubMed ID: 2857608.
    Abstract:
    Agonist regulation of platelet alpha 2-adrenoceptors was examined in human volunteers after acute elevations of adrenoceptor agonist and during chronic elevation of plasma catecholamines in two patients with phaeochromocytoma. Platelet alpha 2-adrenoceptor number was measured by radioligand binding [( 3H]yohimbine) and alpha 2-adrenoceptor function measured by turbidimetric platelet aggregation. Short term infusion of adrenoceptor agonists with alpha 2 activity caused reductions in the platelet response to adrenaline in vitro; conversely an increase in activity was observed postoperatively in two patients after removal of phaeochromocytoma. The changes in platelet response were not accompanied by changes in alpha 2-adrenoceptor number. It is proposed that a process of receptor inactivation occurs during desensitization and this is responsible for the dynamic regulation of platelet responses.
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