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  • Title: A comparison of enriched culture and Xpert polymerase chain reaction assay of Group B streptococcus carrier status at 35-37-week gestation to labor onset: a prospective controlled study.
    Author: Perlitz Y, Ben-Ami M, Megory EC, Nitzan O, Bouganim T, Younis JS, Shapso N, Peretz A.
    Journal: J Matern Fetal Neonatal Med; 2018 Aug; 31(16):2170-2174. PubMed ID: 28583016.
    Abstract:
    OBJECTIVES: (1) To compare the accuracy of vagino-rectal enriched culture (EC) and a rapid polymerase chain reaction (PCR) test for the detection of Group B streptococcus (GBS) carrier status at 35-37-week gestation and at onset of labor. (2) To assess the conversion rate of GBS carrier status between 35-37 weeks to the onset of labor according to the EC/PCR tests. A prospective study was performed at a women's health clinic, referred to give birth at one medical center. STUDY POPULATION: Low risk pregnant women at 35-37-week gestation who did not know their GBS carrier status. METHODS: Participants were evaluated for GBS status both at 35-37 weeks and at labor onset. Correlation between tests was calculated by Spearman correlation. RESULTS: One hundred and ten specimens were analyzed. Correlations: EC-PCR: 35-37 weeks - very high (r = 0.8), at labor - high (r = 0.5). EC-EC: 35-37 weeks and at labor - high (r = 0.39); PCR-PCR: 35-37 weeks and at labor- high (r = 0.7). CONCLUSIONS: Both the EC and Xpert PCR tests are accurate for detecting GBS carrier, both at 35-37 weeks and at labor onset. We did not detect a significant conversion of the GBS status from negative at 35-37 weeks to positive at onset of labor.
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