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  • Title: [Pharmacokinetics of fenazepam and its metabolite 3-oxyfenazepam in animals of different species and in man].
    Author: Zherdev VP, Martynova LA, Caccia S, Garattini S, Ekonomov AL.
    Journal: Farmakol Toksikol; 1985; 48(1):31-5. PubMed ID: 2858403.
    Abstract:
    It has been established that phenazepam is rapidly absorbed from the gastrointestinal tract of animals and man. The maximal concentrations of the unchanged drugs are reached 1, 0.5, 2 and 4 hours in rats, dogs, cats and man, respectively. The half-life of phenazepam in animal and human blood decreases in the following order: man greater than cat greater than dog greater than rat. The metabolite 3 + hydroxyphenazepam was identified in appreciable amounts in cat and rat blood.
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