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Title: Pharmacodynamic Optimization for Treatment of Invasive Candida auris Infection. Author: Lepak AJ, Zhao M, Berkow EL, Lockhart SR, Andes DR. Journal: Antimicrob Agents Chemother; 2017 Aug; 61(8):. PubMed ID: 28584152. Abstract: Candida auris is an emerging multidrug-resistant threat. The pharmacodynamics of three antifungal classes against nine C. auris strains was explored using a murine invasive candidiasis model. The total drug median pharmacodynamic (PD) target associated with net stasis was a fluconazole AUC/MIC (the area under the concentration-time curve over 24 h in the steady state divided by the MIC) of 26, an amphotericin B Cmax/MIC (maximum concentration of drug in serum divided by the MIC) of 0.9, and a micafungin AUC/MIC of 54. The micafungin PD targets for C. auris were ≥20-fold lower than those of other Candida species in this animal model. Clinically relevant micafungin exposures produced the most killing among the three classes.[Abstract] [Full Text] [Related] [New Search]