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  • Title: Effect of implanted ethylene-vinyl alcohol copolymer matrices containing 5-fluorouracil on Ehrlich ascites carcinoma.
    Author: Miyazaki S, Takeuchi S, Sugiyama M, Takada M, Hosokawa M, Koga Y, Kobayashi H.
    Journal: J Pharm Pharmacol; 1985 Jan; 37(1):64-6. PubMed ID: 2858533.
    Abstract:
    The antitumour activity of ethylene-vinyl alcohol (EVAl) copolymer matrices containing 5-fluorouracil (5-FU) was evaluated against Ehrlich ascites carcinoma in mice. A prolongation of the life-span of tumour-bearing mice following intraperitoneal implantation of therapeutic matrices was noted. These results indicated that EVAl matrices containing 5-FU may be effective in cancer chemotherapy. Matrices composed of EVAl copolymer could be useful vehicles for implanted, inserted, or surface-applied delivery systems for anticancer agents.
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