These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: 5-Hydroxytryptamine can antagonize the ability of metoclopramide and SCH 23390 to enhance electrical field stimulation-evoked contractions of guinea-pig isolated stomach muscle.
    Author: Gunning SJ, Naylor RJ.
    Journal: J Pharm Pharmacol; 1985 Jan; 37(1):78-80. PubMed ID: 2858539.
    Abstract:
    Electrical field stimulation of guinea-pig stomach strips caused frequency related contractions that were enhanced by metoclopramide and SCH 23390 (10(-7)-10(-5) M) and antagonized by atropine (5 X 10(-8) M. 5-HT (3 X 10(-8)-3 X 10(-5) M) antagonized the ability of metoclopramide and SCH 23390 to enhance the contractions. It is concluded that metoclopramide and SCH 23390 can enhance electrical field stimulation-induced contractions in the stomach strips by a 5-HT receptor blockade which can facilitate cholinergic mediated contractions.
    [Abstract] [Full Text] [Related] [New Search]