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  • Title: Effects of neuroleptic drugs on brain beta-endorphin immunoreactivity.
    Author: Beal MF, Fisher J, Carr DB, Martin JB.
    Journal: Neurosci Lett; 1985 Jan 21; 53(2):173-8. PubMed ID: 2858834.
    Abstract:
    The effect of chronic haloperidol on brain beta-endorphin immunoreactivity was examined in rats. Chronic haloperidol resulted in significant reductions of beta-endorphin immunoreactivity within the striatum, but other brain regions were uneffected. When a variety of neuroleptic drugs were tested, fluphenazine, chlorpromazine and haloperidol resulted in comparable reductions in beta-endorphin immunoreactivity in the striatum. These findings suggest a functional interaction between beta-endorphin and dopamine systems in the striatum.
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